The role of α5-nicotinic receptors on the effects of early life stress in mouse behaviour
Maria Anna Zafeiraki, Zoi-Maria Thermou, Danai Papavranoussi-Daponte, Irini Skaliora · FENS Forum 2024
Early life stress (ELS) plays a crucial role in shaping adult behaviour and has been implicated as a risk factor in several mental disorders, including schizophrenia. The α5-subunit of the nicotinic acetylcholine receptor (nAChR) has also been associated with disorders such as addiction and schizophrenia. However, the combined effect of ELS and α5-nAChR function remains unexplored. Here, we investigated this interaction by subjecting male and female mice lacking α5-nAChRs (ACNA5) and wild-type (WT) mice to maternal separation (MS) during postnatal days 2-16 (3 hours daily). The animals were ex
ePoster · Neuroscience