Assessment of gradual perceptual learning by behaviour and neuron-glia imaging in AD model mice
Philip Gade Knak, Rune Nguyen Rasmussen, Tatsushi Yokoyama, Masayuki Sakamoto, Maiken Nedergaard, Hajime Hirase, Antonis Asiminas · FENS Forum 2024
Understanding the cellular mechanisms underlying learning and their alteration in Alzheimer’s disease (AD) is crucial for developing targeted therapies. We aimed to elucidate coordinated astrocytic and neuronal activities in learning, with a specific focus on their dynamics influenced by experience and alterations in AD. Using calcium imaging of neurons and astrocytes in the APP/PS1 double transgenic Alzheimer’s disease mouse model, we investigated behavioural and cellular responses to repetitive visual stimuli, in comparison with littermate wild type (WT) mice.We collected data from 32 female
ePoster · Neuroscience