Role of nucleus incertus in shaping interpeduncular nucleus activity – New neuronal mechanism underlying novelty preference in rats
Patryk Sambak, Anna Gugula, Agata Szlaga, Sylwia Drabik, Aleksandra Trenk, Piotr Rywczak, Gniewosz Drwiega, Angelika Kaleta, Tomasz Blasiak, Andrew Gundlach, Anna Blasiak · FENS Forum 2024
Accurate discrimination between new and familiar stimuli is essential for adaptive responses to an ever-changing environment, and disruptions in this process are strongly related to various neuropsychiatric disorders. Stress is a primary mediator of the development of novelty response-related deficiencies; therefore, we investigated the neuronal mechanisms underlying the possible control of the interpeduncular nucleus (IPN), implicated in signaling novelty preference, by the highly stress-sensitive, brainstem nucleus incertus (NI), the primary central source of the neuropeptide, relaxin-3 (RLN