Selective behavioral alterations after acute particulate matter exposure in a pre-symptomatic multiple sclerosis mouse model
Martino Bonato, Roberta Parolisi, Francesca Montarolo, Silvia De Francia, Antonio Bertolotto, Annalisa Buffo, Enrica Boda · FENS Forum 2024
Exposure to air pollution, and particularly to particulate matter (PM), has been associated with higher rates of Multiple Sclerosis (MS) relapses and increased neuroinflammation in MS patients, suggesting that PM exposure may contribute to MS exacerbation. To address this issue, we have combined the induction of MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) in mice – the most used animal model of MS - with PM10 exposure. Mice were exposed to PM10 dosages relevant for human exposure before the immunization or during the pre-symptomatic phase. In both cases, PM10 exposures did
ePoster · Neuroscience