A mouse model to explore clonal evolution in fast-proliferating neuronal progenitor cells during early neurodevelopment
Giulia Di Muzio, Sarah Benedetto, Michelle Krogemann, Franciscus van der Hoeven, Brittney Armstrong, Hsin-Jui Lu, Verena Körber, Nina Claudino, Yassin Harim, Hai-Kun Liu, Thomas Höfer, Pei-Chi Wei · FENS Forum 2024
The human fetal brain shows extensive somatic mosaicism with each embryonic neuronal progenitor cell (NPC) accumulating five mutations daily, whereas postnatal mature neurons accumulate 23 mutations yearly. Somatic mosaicism can contribute to neurodevelopmental disorders like schizophrenia and play a role in interindividual phenotypic differences. Rapid NPC proliferation may cause the high mutation rate, and somatic mutations can alter NPC survival, proliferation, or differentiation, causing clonal selection. Little is known about the mechanisms driving clonal evolution in neurotypical brains
ePoster · Neuroscience