The role of prolactin-releasing peptide (PrRP) in the depressive-like behaviours in rats
Anita Kovács, Evelin Szabó, Kristóf László, László Lénárd, Zsuzsanna Tóth, Balázs Gaszner, Viktória Kormos, Dóra Zelena · FENS Forum 2024
Several data suggest that the RFamide peptides - especially the prolactin-releasing peptide (PrRP) – play a role in the regulation of stress responses, the disturbances of which can cause many diseases, including depression. PrRP was identified as an endogenous ligand of the GPR10 receptor, but can also bind to the NPFF2 receptor. Here we would like to reveal the association between depressive-like behaviour and changes in the PrRP regulation. Fifteen minutes forced swimming test (FST) was used to induce depression-like symptoms in male Wistar rats. On the next day during a 6 min test we ident
ePoster · Neuroscience