Topic: NPHP1-/-

Primary cilia are sensory organelles understood to play important roles throughout development, as evidenced by the spectrum of neurodevelopmental phenotypes observed in instances of ciliary dysfunction (termed ciliopathies). Recent research indicates that in the adult brain, primary cilia may play roles in excitability, maintaining synaptic connectivity, and even form specialised synapses capable of altering the transcriptional landscape of neurons.To further understand the role of cilia in postmitotic neurons, we generated human induced pluripotent stem cell lines (hiPSCs) with NPHP1-/- and