Effects of neuropeptide S receptor signaling on epileptiform activity in the piriform cortex of mice
Ismail Abidin, Harun Başoğlu, Dilanur Köse, Hilal Öztürk, Selcen Aydın-Abidin · FENS Forum 2024
Neuropeptide S is a 20 amino acid neuromodulator and it is the physiological ligand of Neuropeptide S receptor, NPSR. NPSR activates intracellular pathways that control long-term gene expression as well as PLC-Calcium pathway. The expression of the NPS receptor in olfactory regions like piriform cortex, suggests that there may be a functional relationship between NPS and epileptic activity.The aim of this study was to investigate the effects of suppression of the NPS receptor pathway on epileptiform activity in piriform cortex. Acute brain slices were obtained from 6-8 weeks old C57BL/6 mice.
ePoster · Neuroscience