Topic: NR-CA1 pathway

Remembering and responding to aversive events is a crucial evolutionarily conserved behavior. In mammals, regulation of contextual fear memories depends on both medial prefrontal cortex (mPFC), key for extinguishing non-salient fear responses, and dorsal hippocampal CA1 (dCA1), key for encoding contextual memories. However, there is no direct mPFC to CA1 path, leaving unclear how these regions coordinate. A potential route is through the Nucleus Reuniens (NR), a higher-order thalamic region well-connected to emotional regulation areas. NR is driven by mPFC and sends an excitatory monosynaptic