Placental transfer of NMDA receptor autoantibodies impairs correlated network activity by affecting GABAergic neurotransmission
Chuanqiang Zhang, Myrtill Majoros, Vahid Rahmati, Jürgen Graf, Jakob Kreye, Christian Geis, Harald Prüss, Knut Holthoff, Knut Kirmse · FENS Forum 2024
IgG autoantibodies against the GluN1 (NR1) subunit of NMDA receptors underlie the most common form of autoimmune encephalitis, but they are also found in asymptomatic individuals with a reported seroprevalence of up to 1%. Maternal NR1 autoantibodies may actively cross the placenta during pregnancy, reaching the developing brain through the immature blood-brain barrier. However, to what extent prenatal exposure to NR1 autoantibodies influences neuronal circuit maturation remains elusive. We address this question in hippocampal area CA1 using a murine passive-transfer model, in which human mono
ePoster · Neuroscience