Vigilance-state instability precedes state-specific LFP changes in acute sepsis
Susan Leemburg, Annu Kala, Athira Nataraj, Karel Blahna, Karel Jezek · FENS Forum 2024
Sleep-wake disturbances are common in sepsis. We previously hypothesized in an anaesthetized sepsis model, that acute changes in sleep-state dynamics were linked to altered in attractor state dynamics. Here, we studied the acute effects of high-dose LPS injection (5mg/kg) on brain activity in a non-anaesthetized survival model.LFP was recorded from dorsal hippocampus and overlaying cortex of 13 male Long-Evans rats before and after LPS injection. Sleep-wake states were scored for cortex and hippocampus, and analyzed using a 3-D power-spectrum-based state-space approach. Additionally, aperiodic
ePoster · Neuroscience