Noradrenergic locus coeruleus activity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cycle
Georgios Foustoukos, Alejandro Osorio-Forero, Romain Cardis, Laura Fernandez, Najma Cherrad, Christiane Devenoges, Anita Lüthi · FENS Forum 2024
The noradrenergic locus coeruleus (LC) is a fundamental component in the regulation of brain states supporting wakefulness. However, the possibility that it also plays a role for sleep has been around for many years. Gaining a more profound understanding of LC activity in the sleeping brain is crucial for better comprehension of sleep progression in health and disease. Using fiber photometry recordings combined with polysomnography, we show that NREMS alternates between two distinct brain states that arise from infraslow (~50s) activity fluctuations in LC neurons. During NREMS, high LC transie
ePoster · Neuroscience