Korean red ginseng marc-derived gintonin alleviates Alzheimer’s disease-related cognitive dysfunction by stimulating NRF2 pathway and inhibiting p38/NF-κB/STAT3 signaling pathways through LPA receptor 1
Yujeong Ha, Rami Lee, Hyo-Sung Jo, Tae Woo Kwon, Seung-Yeol Nah, Ik-Hyun Cho · FENS Forum 2024
Background: Ginseng is a representative functional food for brain health. However, its active ingredient is not well defined. Gintonin is a novel material isolated from white/red ginseng and its lysophosphatidic acid (LPA) plays as an exogenous G protein-coupled LPA receptor (LPAR) agonist. Korean red ginseng marc (KRGM) is a by-product after KRG extractions. Purpose: In previous study, we demonstrated that KRGM-derived gintonin (KRGM-G) contains LPA C18:2, which is a major functional component, as much as white and/or red ginseng has. Methods: In present study, we further studied KRGM-G-media
ePoster · Neuroscience