Topic: Nrf2 pathway

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. The disease is mainly characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the abnormal accumulation and aggregation of alpha-synuclein (alpha-syn) in the form of Lewy bodies and Lewy neurites. Even if recent studies allowed for an increased understanding of the role of alpha-syn misfolding and aggregation in PD pathogenesis, many other aspects influence disease onset and progression; among them, evidence suggests neuroinflammation as a key factor of PD casca