Neuregulin 1 type III overexpression as a link between schizophrenia spectrum disorder and epilepsy
Mehrnoush Zobeiri, Afsaneh Labbaf, Lennart Polnau, Gilles van Luijtelaar, Thomas Budde · FENS Forum 2024
Altered Neuregulin1 (NRG1) expression and NRG1/ErbB4 signaling are implicated in schizophrenia and temporal lobe epilepsy pathogenesis, however limited research has been done with respect to their role in epilepsy. Our study on HA-Nrg1-tg mice that overexpress the cysteine-rich domain of NRG1-type III, revealed diverse recurrent epileptic seizures characterized by spike and wave discharges (SWDs) in the cortex and thalamus. Seizure expression varied among animals, with slow (4 – 5 Hz) and/or fast (6 - 8 Hz) SWDs present. Slow 4-5 Hz SWDs occurred during passive wakefulness and were abundant du
ePoster · Neuroscience