Topic: Nrxn1+/- mice

The Nrxn1 +/- mouse is a novel strain (Lu H, et al. 2023. Cell Reports. 42:112714), which has not previously been studied for learning and memory performance. Our experiment trained 6-9 month-old male and female Nrxn1+/- and Nrxn1+/+ wildtype (C57BL/6J) mice for odour discrimination learning in an operant olfactometer with a sucrose reward for responding (licking) to the CS+ odour and no reward for responding to the CS- odour. Once the mice had met the criterion of 85% correct, they were tested in a reversal learning paradigm. The total errors made by the Nrxn1+/- mice and wildtype mice were a