Possible role of NKCC1 in the proliferation of hippocampal neural stem cells during Alzheimer's disease
Anna-Lena Fleischer, Magdalene Rippe, Antonia Blank, Gregor Stein, Madlen Haase, Christian A. Hübner, Christian W. Schmeer, Silke Keiner · FENS Forum 2024
Alzheimer´s disease (AD) is one of the main neurodegenerative disorders of the 21st century, characterized by a progressive decline in cognitive function. One important mechanism in memory formation and learning is adult neurogenesis, the process by which new neurons arise from dentate neural stem cells (NSCs). Current research of our group suggests that NSCs are affected in their fate decisions by AD. We observed an increased proliferation of NSCs in the pre-plaque phase which is followed by a strong decline in the number of NSCs and adult neurogenesis. Factors modulating NSC proliferation du
ePoster · Neuroscience