Cell-specific regulation of neuronal and glial glucose metabolism by neurodegeneration-associated protein TDP-43
Ismail Gbadamosi, Lesley Motherwell, Izabela Lepiarz-Raba, Dorota Dymkowska, Ali Jawaid · FENS Forum 2024
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are fatal neurodegenerative disorders with significant clinical and molecular overlaps. Critical events in their pathogenesis involve cytoplasmic mislocalization and loss of nuclear functions of TAR DNA-binding protein 43 (TDP-43). Notably, unconventional metabolic conditions like type 2 diabetes mellitus and dyslipidemia paradoxically correlate with a better prognosis in ALS and FTLD, hinting at potential metabolic pathways in TDP-43-associated neurodegeneration. To better understand the interplay between TDP-43
ePoster · Neuroscience