The developmental effects of repeated antenatal dexamethasone treatment on ADP-mediated and adenosinergic signaling system in the auditory brainstem of C57BL/6 mice
Dunja Dimitrijević, Irena Lavrnja, Marija Adžić-Bukvić, Milorad Dragić, Anđela Stekić, Katarina Mihajlović, Ivan Milenković, Danijela Laketa · FENS Forum 2024
Pregnant women at risk of premature labor receive a single treatment with the synthetic glucocorticoid dexamethasone (DEX) between the 24th and 34th week of pregnancy to ensure adequate maturation of the fetal organs. Due to the postponement of the due date, several doses are often administered. Because purinergic signaling plays an important role in the development of the auditory brainstem, particularly the cochlear nucleus, we investigated whether repeated DEX treatments affect components of the ADP-mediated (NTPDase2 and P2Y1R) and adenosinergic (CD73 and A1R) signaling systems. To compare
ePoster · Neuroscience