Topic: nuclear deformation

Radial glia (RG) are the principal neural stem cells of the embryonic brain, giving rise to neural cell types and serving as mechanical scaffold for neuron migration. Ln2PMMA is an RG biomimetic substrate, of poly methyl methacrylate with 2μm linear topography, that reproduced the surface properties and mechanical anisotropy of the embryonic RG niche. Mechanical signals from ln2PMMA induce cultured astrocytes to dedifferentiate into functional RG. However, the mechanotransducive components underlying this process are largely unknown. We used mouse cortical glial cultures grown on control and l