Specific basal forebrain cholinergic inputs to the ventral prefrontal cortex modulate attention
Giulia Fois, Maria Carmen Medrano, Stephanie Caillé-Garnier, Karine Guillem · FENS Forum 2024
Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is essential to numerous cognitive functions and disruptions of cortical ACh transmission has been implicated in several disorders, including attentional deficit hyperactivity disorder (ADHD), Alzheimer’s disease or schizophrenia and addictive behavior. Similarly in rodents, it has been shown that cognitive functions rely on the mPFC neuronal activity and that ACh release can modulate mPFC neuronal activity thereby altering cognitive behaviors, in particular attention. The main ACh innervation of mPFC originates in basal forebr
ePoster · Neuroscience