Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity
Clara Sanchez, Pascal Noser, Juliette Salvi, Maxime Villet, Ariane Sharif, Ali Altintas, Jean-Louis Nahon, Alexandre Benani, Romain Barrès, Carole Rovère · FENS Forum 2024
Nutrient composition in obesogenic diets may influence the severity of disorders associated with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that obesogenic diets rich in fat and varying in fatty acid composition, particularly in omega 6 (ω6) to omega 3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared
ePoster · Neuroscience