Topic: object location memory

Sleep deprivation is thought to affect 30% of the population worldwide. Yet our understanding of how sleep disorders develop, how to treat them, and how to prevent cognitive impairment associated with lack of sleep remains limited. Previous studies from our lab have suggested that orexinergic inputs to the hippocampus are more active when mice are sleep deprived, but whether this plays a role in the mechanism for disruption of hippocampal memories during sleep deprivation is unknown. We have used excitatory and inhibitory chemogenetic manipulations to bidirectionally modulate orexin neurons' a

Sex and age play significant roles in spatial and contextual memory formation; however, these factors are understudied especially considering the ongoing maturation of prefrontal cortex and hippocampus through juvenility until adulthood. The receptor of Oxytocin (OXTR) has sex-dimorphic characteristics and is expressed in these regions. We previously demonstrated that blockade of prefrontal OXTR impaired extinction of contextual fear memory in juvenile females but not males (Maroun 2020). The hippocampus is central to spatial memory formation and performance in spatial memory tasks is age and