Memory update and hippocampal network deficits in early Alzheimer's disease
Dejana Mitrovic, Can Hicabi Tartanoglu, Maxi Blei, Jill Dorozalla, Marta Sabariego, Matthias Haberl, Silvia Viana da Silva · FENS Forum 2024
Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a significant decline in episodic memory. More recent research indicates that impairments in spatial navigation may serve as a more sensitive biomarker for AD compared to episodic memory alterations. To study the cellular mechanisms behind spatial memory and navigation deficits in AD we used the APP/PS1 mouse model of amyloidosis. To assess spatial memory updating, a non-stressful paradigm called Objects in Updated Locations (OUL) was employed. This task allows the quantification of the different times of ex
ePoster · Neuroscience