Role of GluK1-containing kainate receptors in the development of cortico-striatal projections
Margarita Komarova, Patricia Seja, Julia Glukhova, Maria Ryazantseva, Sari Lauri, Svetlana Molchanova · FENS Forum 2024
Kainate receptors are ionotropic glutamate receptors, involved in modulation of synaptic transmission in developing and adult brain. Genetic disruption of all five kainate receptor subunits reduces cortico-striatal synaptic connectivity and leads to OCD-related pathological behavior. The aim of the project is to evaluate if the OCD-like pathology arises due to the deficit in the development of cortico-striatal projections due to the lack of the kainate receptor subunit 1 (GluK1). We characterized the expression of GluK1 during the development of the cortico-striatal circuitry using immunohisto
ePoster · Neuroscience