Topic: odor-cued delayed non-match-to-sample task

Hippocampal pyramidal (PY) spiking sequences link temporally contiguous memories by encoding sensory cues as well as temporal intervals between them, constructing trajectories across ‘memory-space’. But what is the role of inhibition – particularly parvalbumin (PV) and somatostatin expressing (SST) interneurons (INs) - in shaping such sensory and temporal representations? We pioneered longitudinal, high-frequency voltage imaging in vivo on the CA1 of PV-Cre and SST-Cre mice while they performed an odor-cued delayed non-match-to-sample task (DNMS), shown to yield odor-specific PY sequences duri