Shedding light on object location recall: Optogenetic priming of the HIP-mPFC pathway for object-location memory
Julia Buescher, Nina Wegner, Guilherme Gomes, Hassan Hosseini, Erika Trevino, Magdalena Sauvage, Matthias Prigge · FENS Forum 2024
The ability to recall the spatial location of objects is crucial for our everyday life. Such memory capability relies on the intricate communication between the hippocampus (HIP) and the medial prefrontal cortex (mPFC), and its decline is often observed with aging. Despite progress in understanding the role of HIP-mPFC communication in object memory, approaches to enhance its functionality are very limited. Therefore, we aimed to explore how optogenetic activation (priming) of the HIP-mPFC pathway can facilitate object-location memory in adult and aging mice. For this purpose, we injected mice
ePoster · Neuroscience