ePoster · Neuroscience
Control of RVM to spinal cord pain descending pathway by vlPAG-SST neurons in a physiopathological context
Juliette Viellard, Amalia Lambert-Ringuet, Frédéric Naudet, Rabia Bouali-Benazzouz, Abdelhamid Benazzouz, Pascal Fossat · FENS Forum 2024
Pain is an adaptive and primordial aspect of mammal’s physiology whose role is to warn against potential harmful situations and prevent aggravation of actual physical damages. However, many patients suffer from chronic pain, which overpasses pain’s adaptive trait becoming pathological. Nociceptive signal transmission is first relayed by the spinal cord before reaching the brain through ascending pathways. The control of spinal integration descending pathway is orchestrated by the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). In the RVM, ON, OFF and neutral cells, are respec