Sex-specific effect of perinatal mirtazapine administration and pregestational stress on the excitability of mesolimbic dopamine neurons in rats
Ruslan Paliokha, Daniil Grinchii, Stanislava Bukatova, Roman Dekhtiarenko, Talah Khoury, Michal Dubovicky, Lubica Lacinova, Dremencov Eliyahu · FENS Forum 2024
We previously reported that pregestational chronic unpredictable stress (CUS) and prenatal treatment with the antidepressant mirtazapine alter offspring anxiety and spatial memory (Viñas-Noguera et al. PLoS One 17: e0255546, 2022). The present study was designed to investigate the potential involvement of dopamine transmission in these behavioral changes. Maternal CUS and mirtazapine were administered as previously described. Adult offspring were anesthetized with chloral hydrate and electrodes were placed in the ventral tegmental area. Dopamine neurons were detected and recorded. We found no
ePoster · Neuroscience