The basal forebrain cholinergic system linking olfaction and cognitive function: From basic studies to clinical application
Sae Uchida, Jura Moriya, Daichi Morihara, Fusako Kagitani · FENS Forum 2024
Olfactory dysfunction is a common aspect of normal aging. It is also an early symptom of Alzheimer’s disease (AD). The olfactory bulb, the first processing station of olfactory information in the brain, receives cholinergic basal forebrain input, as does the neocortex and hippocampus contributing cognition and memory, respectively. This study aimed to clarify (1) the role of cholinergic input to the olfactory bulb in adult and aged rats, (2) the relationship between olfaction and cognitive function in older adults.In both adult and aged rats, under anesthesia, unilateral olfactory nerve stimul
ePoster · Neuroscience