Pharmacological activation of the dopamine D4 receptor prevents morphine-induced impairment of adult neurogenesis in the subventricular zone: Functional implications in odor discrimination learning
Belen Gago, Marina Ponce-Velasco, María Ángeles Real, Alicia Rivera · FENS Forum 2024
Morphine reduces adult neurogenesis in the subventricular zone (SVZ) and therefore the integration of newly generated neurons in the local olfactory bulb circuit. However, the effects of opioids drugs on the olfactory perception have been scarce studied, although some data suggests that they interfere with olfactory function, and the underlying mechanisms are unknown. We have previously shown that the activation of the dopamine D4 receptor (D4R) prevents both morphine addiction -by modulating dopamine signaling from nigral dopamine cells- and the development of morphine-induced analgesic toler
ePoster · Neuroscience