Identification of blood and neuronal biomarkers for disease onset and medication response in first-episode psychosis patients
Olga Rivero, Kito McKenzie, Àngela Nativitat, Hristina Uzunova, Alba Postiguillo, María José Escartí, Javier David Lluesma, Maria Dolores Moltó · FENS Forum 2024
Schizophrenia (SZ) is a heterogeneous neuropsychiatric disorder whose complexity has hampered the identification of biomarkers that are actually useful in the clinical practice. Our study is based on the hypothesis that first-episode psychosis (FEP) patients present altered gene expression in blood that correlates with changes in neurons. We have analyzed the expression of genes (associated with SZ in genomic studies) through real-time PCR in peripheral blood from 63 FEP patients and 83 controls. We observed that TOX gene was significantly altered in male patients when compared to male control
ePoster · Neuroscience