Gestational VPA exposure reduces the density of juxtapositions between TH+ axons and calretinin or calbindin expressing cells in the ventrobasal forebrain of juvenile mice
Cintia Klaudia Finszter, Róbert Gergely Kemecsei, Gergely Zachar, Ágota Ádám, András Csillag · FENS Forum 2024
Gestational exposure to valproic acid (VPA) is a valid rodent model of human autism spectrum disorder (ASD). VPA treatment is known to bring about specific behavioral deficits of sociability, matching similar alterations in human autism. Previous quantitative morphometric studies from our laboratory showed a marked reduction and defasciculation of the mesotelencephalic DAergic pathway of VPA treated mice (injected on ED13.5, investigated on PD7), along with a decrease in tissue DA in the nucleus accumbens (NAc), but not in the caudatoputamen (CPu) (assayed by ELISA). In the present study, the
ePoster · Neuroscience