Impaired expression of the placental angiogenic factor CD146 by prenatal alcohol exposure results in disorganized foetal brain vasculature and neurodevelopmental defects
Maryline Lecointre, Camille Sautreuil, Jessica Dalmasso, Alexis Lebon, Matthieu Leuillier, François Janin, Mathieu Lecuyer, Soumeya Bekri, Stéphane Marret, Annie Laquerrière, Carole Brasse-Lagnel, Sophie Gil, Bruno Gonzalez · FENS Forum 2024
Prenatal alcohol exposure (PAE) impairs the “placenta–brain” axis that controls foetal brain angiogenesis. Placental growth factor (PlGF) has been identified as a proangiogenic messenger between these two organs. CD146, a partner of the VEGFR-1/2 signalosome, is involved in placental angiogenesis and exists as a soluble circulating form. The aim of the study was to investigate whether placental CD146 may contribute to brain vascular defects described in foetal alcohol spectrum disorder. In human placenta, the CD146 is expressed in developing villi and membrane and soluble CD146 forms are diffe
ePoster · Neuroscience