Posterior parietal cortex oscillatory activity shapes persistent spatial memory impairments induced by soluble amyloid-β oligomers
Souhail Djebari, Ana Contreras, Raquel Jiménez-Herrera, Victor Castro-Andrés, Guillermo Iborra-Lázaro, Raudel Sánchez-Campusano, Lydia Jiménez-Díaz, Juan D. Navarro-López · FENS Forum 2024
In the initial stages of Alzheimer's disease (AD), the presence of soluble amyloid-β (Aβ) peptides is known to perturb neuronal activity, leading to cognitive decline in advanced stages of the disease. While the hippocampus remains a focal point due to its vulnerability to Aβ, a comprehensive understanding of early-stage AD pathology requires the examination of interconnected neural regions, such as the posterior parietal cortex (PPC). The PPC, intricately linked with the hippocampus and essential to memory functions, particularly spatial memory, is vital for decoding early symptoms and the pr
ePoster · Neuroscience