Activity-dependent regulation of clustered gamma protocadherins (c-γPCDH) expression during circuit assembly in Purkinje cells
Elena Baz Badillo, Vanessa Rouglan, Alexandre Favereaux, Mathieu Letellier · FENS Forum 2024
Neuronal circuits assemble in a non-random fashion, achieving specificity beyond cell-cell apposition. Two mechanisms have been classically proposed to fine-tune brain circuits: activity or genetics-dependent processes. Experimental evidence supports both options, suggesting a balanced contribution of each. In this study, we explored the interplay between synaptic activity and gene expression during developmental critical periods in olivo-cerebellar circuitry. Early postnatally, cerebellar Purkinje cells (PC) are connected by multiple climbing fibers (CF) emerging from the inferior olive in th
ePoster · Neuroscience