Selective inhibition of phosphodiesterase 7 enzymes reduces alcohol drinking and seeking in animal models of alcohol use disorders
Adana Keshishian, Martina Palma, Gregory A. Demopulos, George A. Gaitanaris, Di Qin, Saqib Hussain, Laura Soverchia, Esi Domi, Roberto Ciccocioppo · FENS Forum 2024
Alcohol use disorder (AUD) is a major cause of disabilities and, despite a few medications having been developed, still represents a largely unmet medical need. We have recently developed a new series of brain-penetrant molecules that selectively inhibit phosphodiesterase-7 (PDE7) enzymes. The PDE7 isoform encompasses two members, PDE7A and PDE7B. Both are cAMP-specific enzymes highly expressed in brain regions known to play a role in the modulation of alcohol reinforcement and abuse.Here we tested the effect of OMSPDE79, a selective PDE7 inhibitor, on multiple well-validated models of AUD in