Topic: ON and OFF visual pathways

Amblyopia is a developmental visual disorder of the cerebral cortex that compromises contrast sensitivity, spatial resolution, and shape perception (Kiorpes \& Movshon, 1996; Holmes \& Clarke, 2006). Based on recent studies (Pons et al., 2019; Najafian et al. 2022), we hypothesize that amblyopia differently affects ON and OFF visual pathways and their sampling of visual space in the cortex. We test this hypothesis with a computational model that simulates visual distortions in humans with amblyopia, reported as drawings of grating patterns (Barrett et al., 2003). The grating distortions are si