ePoster · Computational Neuroscience
Movement and stimuli are differentially encoded in on- or off-manifold dimensions revealed by sleep
Eliezyer Fermino de Oliveira,Soyoun Kim,Tian Qiu,Adrien Peyrache,Renata Batista-Brito,Lucas Sjulson · COSYNE 2022
Fri, Mar 18, 2022
Recent work has shown that spontaneous movements are represented throughout the brain, even in sensory areas such as primary visual cortex (V1). Interference between visual stimuli and movement is minimized in V1 because they are encoded in orthogonal subspaces, but it is not known how these subspaces are formed. Here, we report that Neuropixels recordings in mouse V1 during slow-wave sleep (SWS) reveal internally generated low-dimensional manifold structure that is mostly preserved in the awake state. However, the awake state has more variance in “off-manifold” dimensions, defined as those ex