Chaperone mediated autophagy is deficient in spinal motoneurons of ALS patients
Daniel Garrigos, Marta Martínez-Morga, Emilio Geijo-Barrientos, José María Moraleda, Salvador Martinez · FENS Forum 2024
Amyotrophic Lateral Sclerosis (ALS) is an almost selective motoneuron (MN) neurodegenerative disease in which the factors determining preferential involvement of MN are yet to be fully understood. TDP-43 nuclear clearance and aggregates are identified as a major component of the ubiquitinated neuronal cytoplasmic inclusions deposited in spinal motor neurons both in familiar and sALS patients. Since TDP43 protein contains the HSC70 recognition motif, and, therefore, chaperon mediated autophagy (CMA) function may represent a cellular mechanism to regulate TDP43 cytoplasmic turnover in cells. We
ePoster · Neuroscience