Music impact on dopamine dynamics upon opioid-based treatment for chronic pain
Montse Flores-García, África Flores de los Heros, Paloma Otero-López, Ester Aso, Sebastià Videla, Jennifer Grau-Sánchez, Antoni Rodríguez-Fornells, Jordi Bonaventura, Víctor Fernández-Dueñas · FENS Forum 2024
Chronic pain is a major concern in public health. Opioids are effective analgesics, but they may lead to severe adverse effects, including dependence. Non-pharmacological interventions, such as music listening, can be used as adjuvants to analgesics. However, the underlying mechanisms are insufficiently understood. Here, we aimed at assessing whether music exposure can modulate opioid adverse effects by influencing dopamine dynamics in the brain. First, mice underwent surgery to inject a dopamine biosensor (Dlight 1.3b) and to implant a fiberoptic in the nucleus accumbens (NAcc). After allowin
ePoster · Neuroscience