Dopamine D3R antagonism facilitates the extinction of drug-seeking behaviours in opiate CPA model and is associated with decreased Iba1 levels in the medial prefrontal cortex
Aurelio Franco-García, Victoria Gómez-Murcia, M. Victoria Milanés, Cristina Núñez · FENS Forum 2024
Opioid misuse for pain management has become a major global health problem, causing what has been called the opioid epidemic. Recently, D3 receptor (D3R) antagonists have arisen as a potential treatment to enhance cognition in memory-related diseases. In this work, we first used a 3-day extinction training (ET) previously reported to be successful to extinguish opiates-seeking behaviours motivated by their withdrawal-related contextual memories, such as the morphine withdrawal-induced conditioned place aversion (CPA) in rats. Secondly, we evaluated the impact of D3R blockade in the extinction
ePoster · Neuroscience