Development and application of L-shaped vertical micro-coils for in vivo neurostimulation in two-photon microscopy
Xiyuan Liu, Kayeon Kim, Changsi Cai, Shelley Fried, Anpan Han · FENS Forum 2024
Micro-coils were designed to selectively activate pyramidal neurons (PNs), avoiding axonal stimulation, and potentially overcoming the limitations of conventional electric stimulation[1][2]. Finite element simulations showed a significant impact of micro-coil design on neuron activation selectivity[3]. A V-shaped bend at the micro-coil tip-enhanced field gradient selectivity vertically, leading to spatially confined cortical activation. In previous in vivo experiments, extracellular electrodes were necessary for recording neuronal action potentials, potentially increasing brain tissue damage[4
ePoster · Neuroscience