Topic: optogenetic engram reactivation

Sleep deprivation (SD) negatively affects memory processes, particularly in the hippocampus. Previous research indicates that 6 hours of SD post-learning causes amnesia in hippocampus-dependent tasks. However, we recently demonstrated that object-location memories (OLMs) formed under SD conditions can be effectively recalled several days later using optogenetic engram reactivation or administration of the PDE4 inhibitor roflumilast. These findings suggest that these memories are not lost, but merely difficult to retrieve.Since both cAMP and cGMP signalling critically contribute to memory proce