An interpretable spline-LNP model to characterize feedforward and feedback processing in mouse dLGN
Lisa Schmors,Yannik Bauer,Ziwei Huang,Lukas Meyerolbersleben,Simon Renner,Ann H. Kotkat,Davide Crombie,Sacha Sokoloski,Laura Busse,Philipp Berens · COSYNE 2022
Thu, Mar 17, 2022
The dorsolateral geniculate nucleus (dLGN) of the thalamus is an essential processing stage for retinal signals to reach the primary visual cortex (V1). How these feedforward signals are modulated by corticothalamic (CT) feedback and behavior remains an open question. To quantify how feedforward, feedback and behavior combine in shaping dLGN responses, direct and selective control of CT feedback in behaving animals is needed, as well as a computational model that takes the various contributing factors into account. We here recorded extracellular responses in dLGN of awake mice to a rich, dynam