Topic: optogenetic interventions

Systems consolidation is a process by which new experiences are initially encoded in the hippocampus and subsequently transferred to the cortex, facilitating integration into long-term memory networks. Our recent study showed that the precise temporal dynamics of cross-area coupling between prefrontal cortex (PFC) and primary motor cortex (M1) can demarcate the transition to cortical stabilization and task performance, reducing involvement of the hippocampus. Here, we demonstrate the causal role of precise coupling in PFC-M1 sleep slow oscillation (SO) for motor memory stabilization. Using a s