Sleepless nights, vanishing faces: The effect of sleep deprivation on long-term social recognition memory in mice
Adithya Sarma, Evgeniya Tyumeneva, Junfei Cao, Soraya Smit, Marit Bonne, Fleur Meijer, Jean-Christophe Billeter, Robbert Havekes · FENS Forum 2024
Sleep deprivation (SD) detrimentally affects hippocampal-dependent memories, notably spatial and fear memories. However, its effect on social recognition memory — crucial for identifying conspecifics, remains unexplored. To address this, we developed a novel protocol to study the effects of SD on long-term social recognition memory (SRM) in adult male C57BL/6J mice. Our study revealed that 6 hours of SD, following a socialization trial, caused amnesia when SRM was assessed 24 hours later.Next, we investigated whether SD causes permanent loss or suboptimal storage of SRM. We employed mouse mode
ePoster · Neuroscience