Topic: optogenetic stimulations

The sudden emergence of dangerous seizures is the defining feature of epilepsy, but how and when the brain changes dynamics remains enigmatic. From the perspective of dynamical systems theory, such critical transitions occur upon inconspicuous perturbations in highly interconnected systems presenting positive feedback loops and can be modeled as mathematical bifurcations between alternative regimes. Here, we sought to characterize dynamical signatures of impending seizures. We systematically verified the predictions of the model called ‘Epileptor’ that captures seizure dynamics in five differe