Synapse-specific investigation of the single-cell gene regulatory dynamics to reveal the molecular basis of plasticity in aversive memory formation
Valentina Khalil, Kaho Ito, Islam Faress, Sadegh Nabavi, Taro Kitazawa · FENS Forum 2024
It is widely accepted that experience-dependent plasticity is required for memory formation. However, underlying transcriptional and epigenetic changes are poorly understood.This project aims to deepen our understanding of the gene regulatory dynamics underpinning memory formation and how it is orchestrated with synaptic plasticity.To this end, we first characterized the immediate early genes (IEGs) and the secondary response genes (SRGs) at several time points after aversive learning from FACS-isolated cFOS-expressing mouse amygdalar nuclei. We performed RNA-seq to investigate the experience-
ePoster · Neuroscience