Topic: Orexins

Spinal cord injury immediately impairs movement control and other essential physiological functions. Evidence has shown that a large-scale network including spinal and supraspinal structures is recruited after SCI to promote functional recovery. Orexins (hypocretins), known for promoting wakefulness, arousal, and reward-seeking behaviours, also influence muscular tone, locomotion initiation, and skilled performance, exerting a multi-systemic effect on motor control predisposing for movement execution. Despite the potential relevance of orexin transmission in motor recovery after CNS damage, th